Bring a large pot of salted water to a boil and cook the penne pasta according to package directions until al dente.
While the pasta cooks, melt butter in a large skillet over medium heat. Add the diced onion and sauté for 4 to 5 minutes until soft and translucent.
Add the salmon fillet to the skillet and cook for 5 to 7 minutes, breaking it into flakes as it cooks.
Once the salmon is cooked through, pour in the heavy cream, adding salt and pepper. Stir gently and turn off the heat.
Drain the pasta and add it to the skillet with the salmon and cream mixture. Sprinkle the grated Parmigiano Reggiano over the pasta and toss to combine.
Stir in the chopped parsley and serve hot, garnished with additional cheese and parsley if desired.
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Notes
Store leftovers in an airtight container in the fridge for up to 4 days. Reheat gently to maintain creaminess.